Sulbutiamine is a form of Vitamin B1 that was discovered in Japan. Studies have shown that it improves memory through the potentiation of cholinergic and dopaminergic transmission. While the exact mechanism of action is unknown, it is thought to occur through the upregulation of the reticular activating system, which is the center of arousal and motivation in the brain.

Pharmacologic and therapeutic features of sulbutiamine.

Van Reeth O.

Centre d’Etude des Rythmes Biologiques,
School of Medicine,
Universite Libre de Bruxelles,
Brussels, Belgium.
Drugs Today (Barc). 1999 Mar;35(3):187-92.

Asthenia is the most frequent medical reason for people seeking help from their physician. In 75% of cases, the cause is functional (either reactive or psychiatric) and in 25% it is organic. In order to provide patients with rapid relief of symptoms, appropriate antiasthenic treatment should be initiated immediately, while at the same time, adequate clinical and laboratory assessments should be performed to detect the underlying cause of asthenia. Sulbutiamine, a highly lipophilic thiamine derivative, is the only antiasthenic compound known to cross the blood-brain barrier and to be selectively active on specific brain structures directly involved in asthenia.

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