Galantamine in Alzheimer’s Disease: The Galantamine USA-1 Study Group

Galantamine in Alzheimer’s Disease
A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group.

Raskind MA, Peskind ER, Wessel T, Yuan W.

Veteran Affairs Puget Sound Health Care System
and the Department of Psychiatry and Behavioral Sciences,
University of Washington, Seattle 98108, USA.

Abstract

BACKGROUND: Galantamine is a reversible, competitive cholinesterase inhibitor that also allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action provided the rationale for a therapeutic trial of galantamine in AD.

METHODS: A 6-month, multicenter, double-blind trial was undertaken in 636 patients with mild to moderate AD. Patients were randomly assigned to placebo or galantamine and escalated to maintenance doses of 24 or 32 mg/d. Eligible patients then entered a 6-month, open-label study of the 24 mg/d dose. Primary efficacy measures were the 11-item AD Assessment Scale cognitive subscale (ADAS-cog/11) and the Clinician’s Interview-Based Impression of Change plus Caregiver Input (CIBIC-plus). The Disability Assessment for Dementia (DAD) scale was a secondary efficacy variable.

RESULTS: Galantamine significantly improved cognitive function relative to placebo; the treatment effects were 3.9 points (lower dose) and 3.8 points (higher dose) on the ADAS-cog/11 scale at month 6 (p < 0.001 in both cases). Both doses of galantamine produced a better outcome on CIBIC-plus than placebo (p < 0.05). Therapeutic response to galantamine was not affected by APOE genotype. At 12 months, mean ADAS-cog/11 and DAD scores had not significantly changed from baseline for patients who received galantamine 24 mg/d throughout the 12 months. The most common adverse events, which were predominantly gastrointestinal, decreased in frequency during long-term treatment. There was no evidence of hepatotoxicity.

CONCLUSIONS: Galantamine is effective and safe in AD. At 6 months, galantamine significantly improved cognition and global function. Moreover, cognitive and daily function were maintained for 12 months with the 24 mg/d dose.

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Research abstracts
Galantamine: its use in Alzheimer’s
Galantamine: in Alzheimer’s patients
Galantamine: acetylcholinesterase inhibition
Galantamine: therapeutic effects beyond cognition
Galantamine: benefits to Alzheimer’s patients
Galantamine: nicotinic receptors modulation in Alzheimers’s
Galantamine: a study in Alzheimer’s
Galantamine: its effects on Alzheimer’s
Galantamine: a new treatment for Alzheimer’s
Galantamine: effect on nicotinic receptor binding
Galantamine: an allosterically potentiating ligant
Galantamine: nicotinic modulation in an animal model
Galantamine: memory & nicotinic receptors effect in rats
Galantamine: a 6 month study: