Galantamine, a cholinesterase inhibitor

Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer’s disease

Coyle JT, Kershaw P

Biol Psychiatry 2001 Feb; 49 (3) 289-299

Abstract

Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer’s disease, there is a need for new and more effective treatments. Galantamine is a novel treatment for Alzheimer’s disease that inhibits acetylcholinesterase and modulates nicotinic receptors. In randomized, double-blind, placebo-controlled studies of up to 6 months duration, galantamine significantly improved cognitive function. Galantamine also had beneficial effects on instrumental and basic activities of daily living, and postponed the progression of behavioral symptoms. Patients who completed one of the 6-month, placebo-controlled studies were eligible to enter a 6-month, open-extension study of the 24-mg/day dose of galantamine. At the end of 12 months, cognitive function and activities of daily living were preserved in those patients who had been treated throughout the study with galantamine 24 mg/day. At 12 months, this group of patients had significantly better cognitive functions than patients who had been treated with a placebo for 6 months before receiving galantamine. These studies indicate that galantamine postpones the progression of symptoms in Alzheimer’s disease. Since galantamine shows the greatest benefits when treatment is started early, its long-term benefits may result from an effect on the underlying disease process; such an effect might be mediated by galantamine’s concomitant action on nicotinic receptors.

BACK

to order

Articles
Galantamine boosts memory
Galantamine food for mind and body
Galantamine rescues brain cells
Galantamine and memory enhancement
Galantamine fights Alzheimer’s
Galantamine the old become young
Research abstracts
Galantamine: its use in Alzheimer’s
Galantamine: in Alzheimer’s patients
Galantamine: acetylcholinesterase inhibition
Galantamine: therapeutic effects beyond cognition
Galantamine: benefits to Alzheimer’s patients
Galantamine: nicotinic receptors modulation in Alzheimers’s
Galantamine: a study in Alzheimer’s
Galantamine: its effects on Alzheimer’s
Galantamine: a new treatment for Alzheimer’s
Galantamine: effect on nicotinic receptor binding
Galantamine: an allosterically potentiating ligant
Galantamine: nicotinic modulation in an animal model
Galantamine: memory & nicotinic receptors effect in rats
Galantamine: a 6 month study: