|
N-Acetyl
Carnosine eyedrops
Second interview with Mark Babizhayev,
Ph.D.
At the 1st Paris Anti-Aging Conference, February,
2003, Dr. Babizhayev talked about the Russian breakthrough of
N-acetyl carnosine for the treatment of senile cataract.
Question: “Dr. Babizhayev, we have already covered
a lot in our previous article and interview, about the development of
N-acetyl carnosine and its role in combating the common aging-disease of
senile cataract.“
Dr. Babizhayev: ”Yes, N-acetyl carnosine
protects the lens proteins from the singlet oxidation by scavenging the
hydroxyl radical, singlet oxygen, lipid peroxidase-like and
ferroxidase-like activities.
The ratio of carnosine/NAC concentrations upon the topical
application of Can-C to the eye, is equal to 9 in the aqueous humor.
This means that virtually all N-acetyl carnosine is converted to the more
powerful antioxidant L-carnosine in the aqueous humor. This can then
enter the lens tissue and epithelial cells, and act as the anti-cataract
remedy.
N-acetyl carnosine is a delicate molecule. The
biotransformation of N-acetyl carnosine into L-carnosine in unsolicited
external topical formulations, can be promptly inhibited. Active
L-carnosine can not be detected in the aqueous humor after the topical
installation of hydrophobic vitamin-loaded remedies after 15 minutes, at
any significant doses.
It is not apparent that when chemicals are mixed
together, chemicals which, by themselves may have efficacy, that the sum
is greater than the single parts. These chemicals interact with one
another, and in the eye, these additional interactions could cause side
effects or lose the efficacy of the original product.”
Question: “I appreciate that it is still early
days, but do you feel, or do you have any scientific reasoning, if
N-acetyl carnosine will be useful in other eye-disorders?”
Dr. Babizhayev: “Yes, we believe that
N-acetyl carnosine will have a role for glaucoma, especially when
combined with some other substances that we are currently working on. In
particular, we know that N-acetyl carnosine is efficacious for its
anti-glare effect and improvement for color vision. So, for example, we
envisage that this could lead to safer driving, especially night
driving.
Another interesting, recent development is the
fact that we have shown N-acetyl carnosine to prevent and reverse the
acidosis in the corneal stroma due to the actions of accumulated lactic
acid. This means that individuals can wear contact lenses, particularly
soft contact lenses, which are not gas permeable, for longer and with
more comfort.”
Question: “What kind of response are you
getting to your trials that show N-acetyl carnosine to be highly
efficacious in the prevention and treatment of senile cataract?”
Dr. Babizhayev: “Yes, the response wherever
I go is very favorable and I think that eventually the word about this
breakthrough is going to spread worldwide. We are close to some
arrangements that would probably mean the general media would know and
report about this, when that happens I expect much will change quickly.”
Question: “Thank you for your time.”
Dr. Babizhayev: “Thank you.”
Can C ingredients
Active ingredients Glycerin (lubricant) 1.0%
Hydroxypropylmethylcellulose (lubricant) 0.15%
Inactive Ingredients Sterile water (ophthalmic grade isotonic solution, pH 6.4 to
6.5); antioxidants N-Acetyl-Carnosine (NAC) 1.0%, buffered with boric acid,
citric acid, and
potassium bicarbonate and as a preservative, purified benzyl alcohol.
|
