N-Acetyl Carnosine eyedrops
Second interview with Mark Babizhayev, Ph.D.
At the 1st Paris Anti-Aging Conference, February, 2003, Dr. Babizhayev talked about the Russian breakthrough of N-acetyl carnosine for the treatment of senile cataract.
Question: “Dr. Babizhayev, we have already covered a lot in our previous article and interview, about the development of N-acetyl carnosine and its role in combating the common aging-disease of senile cataract.”
Dr. Babizhayev: “Yes, N-acetyl carnosine protects the lens proteins from the singlet oxidation by scavenging the hydroxyl radical, singlet oxygen, lipid peroxidase-like and ferroxidase-like activities.
The ratio of carnosine/NAC concentrations upon the topical application of Can-C to the eye, is equal to 9 in the aqueous humor. This means that virtually all N-acetyl carnosine is converted to the more powerful antioxidant L-carnosine in the aqueous humor. This can then enter the lens tissue and epithelial cells, and act as the anti-cataract remedy.
N-acetyl carnosine is a delicate molecule. The biotransformation of N-acetyl carnosine into L-carnosine in unsolicited external topical formulations, can be promptly inhibited. Active L-carnosine can not be detected in the aqueous humor after the topical installation of hydrophobic vitamin-loaded remedies after 15 minutes, at any significant doses.
It is not apparent that when chemicals are mixed together, chemicals which, by themselves may have efficacy, that the sum is greater than the single parts. These chemicals interact with one another, and in the eye, these additional interactions could cause side effects or lose the efficacy of the original product.”
Question: “I appreciate that it is still early days, but do you feel, or do you have any scientific reasoning, if N-acetyl carnosine will be useful in other eye-disorders?”
Dr. Babizhayev: “Yes, we believe that N-acetyl carnosine will have a role for glaucoma, especially when combined with some other substances that we are currently working on. In particular, we know that N-acetyl carnosine is efficacious for its anti-glare effect and improvement for color vision. So, for example, we envisage that this could lead to safer driving, especially night driving.
Another interesting, recent development is the fact that we have shown N-acetyl carnosine to prevent and reverse the acidosis in the corneal stroma due to the actions of accumulated lactic acid. This means that individuals can wear contact lenses, particularly soft contact lenses, which are not gas permeable, for longer and with more comfort.”
Question: “What kind of response are you getting to your trials that show N-acetyl carnosine to be highly efficacious in the prevention and treatment of senile cataract?”
Dr. Babizhayev: “Yes, the response wherever I go is very favorable and I think that eventually the word about this breakthrough is going to spread worldwide. We are close to some arrangements that would probably mean the general media would know and report about this, when that happens I expect much will change quickly.”
Question: “Thank you for your time.”
Dr. Babizhayev: “Thank you.”
Can C ingredients
Active ingredients Glycerin (lubricant) 1.0% Hydroxypropylmethylcellulose (lubricant) 0.15%
Inactive Ingredients Sterile water (ophthalmic grade isotonic solution, pH 6.4 to 6.5); antioxidants N-Acetyl-Carnosine (NAC) 1.0%, buffered with boric acid, citric acid, and potassium bicarbonate and as a preservative, purified benzyl alcohol.
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 ingredients in 2 capsules
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